Protein Science

Role Summary

The Director / Senior Director of Protein Sciences will lead the production and characterization of next-generation biologics, including multispecific antibodies and engineered fusion proteins. This leader will shape BraneX’s protein sciences strategy, integrating innovation in antibody engineering, molecular design, and analytical characterization to enable rapid, high-quality therapeutic advancement. The role reports to the Chief Scientific Officer and works closely with internal teams in Biology, Assay Development, and CMC, as well as with external CROs, CDMOs, and other industry partners.

Key Responsibilities:

• Lead the expression, purification, and characterization of antibody-based therapeutics (monospecifics, bispecifics, Fc fusions, and conjugates).
• Drive innovation in biologics production — including heterodimerization control, conjugation (enzymatic, click, or linker-based), and modular payload formats (peptide, oligo, or protein).
• Build and oversee robust workflows for high-throughput protein production, analytical and developability characterization, integrating automation and informatics where appropriate.
• Apply biophysical, biochemical, and structural analyses (e.g., HPLC, MS, BLI, DSC, DSF, ITC, SPR, ELISA, CE-SDS) to ensure optimal developability and stability of molecules.
• Partner with CMC, toxicology, and translational functions to progress molecules toward IND-enabling studies.
• Establish and manage productive relationships with CROs and CDMOs for antibody discovery, characterization, and manufacturing.
• Identify and integrate emerging technologies (e.g., AI-driven design, machine learning-guided developability prediction, or microfluidics-based screening) to strengthen BraneX’s platform.
• Mentor and grow a high-performing Protein Sciences team while fostering scientific rigor, collaboration, and innovation.
• Ensure strong documentation and data integrity (ELN/SOP discipline) in support of IP, regulatory filings, and data room readiness.

Minimum Qualifications:

• PhD in Biochemistry, Molecular Biology, Structural Biology, or related field.
• ≥10 years of postdoctoral experience, including ≥5 years in a biotech or pharma setting with demonstrated impact in biologics discovery or engineering.
• Deep expertise in antibody and bispecifics expression, purification, and characterization; proven track record of advancing biologics toward development candidates.
• Demonstrated experience with biophysical and biochemical methods supporting protein stability, binding, and developability.
• Experience balancing internal and outsourced workflows and managing cross-functional scientific projects.
• Strong leadership, communication, and mentoring skills, with the ability to inspire a multidisciplinary team in a fast-paced startup environment.
• Strong ELN/SOP discipline and data-driven mindset.

Preferred Qualifications:

• Experience with early cell line development and technology transfer to manufacturing partners.
• Hands-on experience with protein conjugation and linker chemistry (e.g., for peptide or oligonucleotide cargoes).
• Familiarity with automation platforms (e.g., liquid handlers, chromatography automation, or analytics) for scale and reproducibility.
• Proven track record advancing biologics from discovery to IND or early clinical stage.

Success Metrics:

• Deliver 3–5 engineered leads per year meeting predefined developability and binding criteria.
• Achieve early-stage developability screening that mitigates liabilities (aggregation, PTMs, stability) pre-in vivo.
• Generate high-quality, traceable data packages and documentation supporting IP filings and partnership readiness.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Role Summary

The Director / Senior Director of Neuroscience Biology is responsible for the execution of the company’s overall research strategy focusing on neuroscience diseases. She/he will provide scientific leadership and build biology team for preclinical projects and supporting the initiation and advancement of innovative drug programs. This leader will participate to shape BraneX Bio’s therapeutics evaluation strategy, design and refine flow scheme assays to enable rapid, high-quality therapeutic advancement. The role reports to the Chief Operating Officer and works closely with internal biologics team as well as with external CROs, CDMOs, and other industry partners.

Key Responsibilities:

• Evaluate emerging scientific directions and technological trends relevant to neuroscience drug discovery.
• Lead the biology research team in new target discovery and validation, and establish relevant in vitro biological assays.
• Oversee the development and implementation of in vivo pharmacology models and efficacy testing methods.
• Manage the progress and timelines of the company’s R&D projects to ensure milestones are achieved efficiently.
• Collaborate with multidisciplinary experts to advance projects; participate in CRO selection, coordination and supervision to ensure scientific data quality and project milestone achievement.
• Maintain collaborations with domestic and international academic institutions and participate in the communications with scientific advisory board.
• Contribute to the growth of internal biology teams and laboratory infrastructure to support long-term R&D growth.

Minimum Qualifications:

• PhD in Biochemistry, Molecular Biology, Cell Biology, Neuroscience or related fields.
• ≥10 years of postdoctoral experience, including ≥5 years in a biotech or pharma setting with demonstrated impact in advancing portfolio programs into      PCC/IND stages.
• Deep expertise in CNS biology, including one or more of the following: neurobiology,      glia biology, neuroimmunology or CNS pharmacology.
• Hands-on experience with relevant in vitro and in vivo model systems of CNS diseases; familiarity with translational biomarkers and clinical relevance of preclinical findings.
• Strong communication skills in both English and Chinese, with demonstrated ability in organization, coordination, and team leadership.
• Strong analytical and logical reasoning abilities, high self-motivation, and a strong sense of responsibility.

Preferred Qualifications:

• Proven track record advancing therapeutics from discovery to early clinical stage.
• Strong ability to think strategically while maintaining operational excellence in project execution.
• International R&D experience and/or prior leadership in cross-site or cross-disciplinary collaborations preferred.

Success Metrics:

• Together with biologics team, deliver 3–5 engineered leads per year meeting      predefined pharmacology and developability criteria.
• Implementation of high-quality flow schemes and/or analytical platforms (e.g. AI analysis, advanced CNS models, novel technology platform ).
• Generate high-quality, traceable data packages and documentation supporting IP filings and partnership readiness.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Role Summary

The Director/Senior Director of Oligonucleotide CNS Drug Discovery will participate in the strategic design, and lead the advancement of siRNA and/or antisense oligonucleotide (ASO) as well as Antibody–oligonucleotide conjugate (AOC) therapeutics for central nervous system (CNS) indications. This role will drive early discovery through IND-enabling activities, integrating oligonucleotide/linker chemistry, delivery technologies, target biology and translational science for high quality compound generation and milestone achievements. The successful candidate will report to the Chief Scientific Officer and provide scientific leadership, and work closely with internal teams in Biology, Assay Development, Translational Science, CMC, as well as with external CROs, CDMOs and other industry partners.

Key Responsibilities:

• Lead discovery programs focused on oligonucleotide therapeutics (ASO, siRNA, AOC)      for CNS diseases.
• Oversee design, screening, and optimization of oligonucleotide candidates (chemistry, backbone modification, conjugation) and guide CNS delivery strategy
• Participate in vitro and in vivo pharmacology studies, including PK/PD modeling,      biodistribution, and safety pharmacology.
• Establish translational frameworks linking target modulation to disease-relevant biomarkers and clinical endpoints.
• Support IND-enabling studies and regulatory documentation in collaboration with CMC, toxicology, and clinical teams.
• Manage external CROs and academic collaborations.
• Contribute to portfolio prioritization and long-term platform strategy.
• Present program updates to governance committees and executive leadership.
• Partner with BD to evaluate in-licensing or platform opportunities.
• Foster a culture of scientific rigor, innovation, and accountability.

Minimum Qualifications:

• Ph.D. in Chemistry, Pharmacology, or related fields.
• >5 years of relevant industry experience in drug discovery.
• Demonstrated experience with oligonucleotide therapeutics (siRNA/ASO, AOC).
• Track record of advancing programs from early discovery into IND-enabling stages.
• Strong written and verbal communication skills. Experience in balancing internal and      outsourced workflows and managing cross-functional scientific projects.
• Solid ELN/SOP discipline and data-driven mindset.

Preferred Qualifications:

• Experience in neurodegeneration, neuroimmunology, or rare genetic CNS      disorders is highly desired.
• >5 years of experience advancing CNS oligonucleotide or AOC programs into clinical development.
• Broad expertise in CNS delivery technologies and biodistribution assessment.
• Experience with biomarker strategy and translational neuroscience.
• Familiarity with regulatory expectations for RNA therapeutics.
• Strong leadership, communication, and mentoring skills, with the ability to inspire a multidisciplinary team in a fast-paced startup environment.
• Demonstrated publication or patent record in RNA therapeutics or neurobiology.

Success Metrics:

• Establishment of oligonucleotide medicine workflow with scalable screening and validation procedures.
• Deliver 1-2 leads per year meeting predefined potency and efficacy criteria.
• Generate high-quality, traceable data packages and documentation supporting IP filings and partnership readiness.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.