Senior / Principal Scientist, Protein Sciences

Role Summary

The Senior Scientist / Principal Scientist in Protein Sciences will contribute to the design, production, and characterization of next-generation biologics, including multispecific antibodies and engineered fusion proteins. This role is ideal for a hands-on scientist who enjoys solving technical problems, generating high-quality data, and collaborating closely with cross-functional teams to advance therapeutic candidates. The position reports to the Head of Protein Sciences and works closely with internal teams in Biology, Assay Development, and CMC, as well as external partners.

Key Responsibilities:

•  Design, express, purify, and characterize antibody-based therapeutics, including monospecific and bispecific antibodies, Fc fusion proteins, and conjugated biologics
• Execute protein production workflows from construct design through purification and analytical characterization
• Perform and interpret biophysical and biochemical assays to evaluate protein quality and developability, including HPLC, SEC, mass spectrometry, BLI / SPR, DSC / DSF, ELISA, and CE-SDS
• Troubleshoot expression, purification, and stability challenges to improve yield, purity, and manufacturability
• Support evaluation of new technologies and methods, such as improved expression systems, conjugation strategies, automation tools, developability screening approaches 
• Document experimental procedures and results clearly in ELN systems in accordance with SOPs
• Work closely with cross-functional teams to advance molecules toward in vivo studies and development
• Coordinate with external CROs and CDMOs for protein production and characterization activities
• Participate in project discussions and provide technical input on molecular design and developability

Minimum Qualifications:

• Master’s or PhD in Biochemistry, Molecular Biology,  Structural Biology, or related field
• ≥4 years (post Master’s) of industry or academic experience with demonstrated impact in biologics production and characterization
• Hands-on experience with antibody or protein expression, protein purification, and analytical characterization
• Working knowledge of developability concepts including aggregation, stability, binding affinity, and manufacturability 
• Strong organizational skills and attention to detail
• Ability to work independently while collaborating effectively within a team
• Strong ELN/SOP discipline and data-driven mindset

Preferred Qualifications:

• Experience with bispecific antibodies, fusion proteins, conjugated biologics 
• Familiarity with protein conjugation or linker chemistry, automated purification or analytical platforms and outsourcing workflows with CRO/CDMO partners 
• Experience supporting molecules advancing into in vivo studies, development candidate selection, and IND-enabling work

Success Metrics:

• Reliable production of high-quality proteins meeting project specifications
• Timely completion of experimental plans and delivery of reproducible data
• Identification and resolution of protein developability issues early in the workflow
• Effective collaboration with internal teams and external partners
• Strong documentation and data integrity

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Please contact Ray Wu for more information:   ray.wu(at)branexbio.com

Role Summary

This position will be responsible for Biologics engineering and characterization. This position will report to Director of Biologics engineering and work closely with scientists from Biology and Protein Science teams. The position requires the candidate to carry out CADD/AIDD based Biologics engineering, including antibody humanization, affinity tuning, liability removal, and pH dependence; Biologics characterization, including binding assays, Tm, Tagg, HIC, DLS, and SPR.

Minimum Qualifications:

• PhD in Structure biology, Biochemistry, or related field with 2+ years post doc or industry experience, or Master with 5+ years in therapeutic antibody engineering.
• Proven record of any of the following: engineering antibodies/Fc-fusions, affinity / epitope tuning via structure guided engineering, phage / yeast / mammalian display technologies.
• Deep knowledge of antibody structure-function relationships and rational design, including utilization of protein design tools like PyMol, Alphafold, Discovery studio/Schrodinger/MOE, and etc.
• Solid wet lab training in any of the following: a. HPLC/UHPLC handling, including SEC, HIC, CIC, RP, CEX, and etc; b. SPR affinity determination; c. display library construction & screening, including phage, yeast or cell-based.
• Rigorous scientific thinking, highly self-motivated, and a strong sense of responsibility.

Preferred Qualifications:

• Programming skills to accelerate Biologics engineering.
• Strong communication skills in English.
• Flexibility and passion in continuous evolvement of technical platform.
• Awareness of whole process of therapeutical biologics Research & Development.

Success Metrics:

• Deliver 3–5 engineered leads per year that meet predefined binding kinetic + developability criteria. 
• Reduce aggregation/ liabilities pre-in vivo; demonstrate cross-reactive binders (e.g., human & cyno) for key targets. 
• High-quality documentation: traceable ELN, assay reports suitable for data room and IP filings. 

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Please contact Ray Wu for more information:   ray.wu(at)branexbio.com

BraneX Bio Introduction:

Central nervous system (CNS) disorders remain one of the greatest unmet medical needs. Despite major advances, effective neurotherapeutics remain limited in part by the blood–brain barrier (BBB). BraneX Bio is an early-stage company backed by leading investors and experienced biotech executives. We are building precision brain-exposure platforms to unlock multiple modalities and advance a focused pipeline of first- and best-in-class therapeutics. If you are driven to build, innovate, and move science toward patients, you’re ready for BraneX.

Key Responsibilities:

• Conduct  bench-level experiments with strict adherence to lab standards, ensuring high data accuracy and reproducibility.
• Proficient in mammalian cell culture experiments. Adequate in performing core molecular biology techniques (e.g., transfection, Western blotting, ELISA, nucleic acid extraction, qRT-PCR, immunofluorescence).
• Assist in experimental design and optimization; accurately analyze data and draft comprehensive lab reports.
• Oversee daily lab operations, including equipment maintenance, reagent inventory management, and hazard prevention.
• Maintain a safe, orderly workspace in full compliance with EHS (Environmental Health and Safety) and biosafety guidelines.
• Collaborate effectively with team members on research tasks and actively engage in technical training to advance scientific expertise.

 Qualifications: 

• MS with >1 years of work experience or PhD in Neurobiology, Molecular Biology, Cell Biology, or a related scientific discipline. Experience in Industrial cellular/ neurobiological settings is highly preferred.
• Strong benchwork proficiency with demonstrated expertise in cellular and molecular techniques. Experience with iPSC-based or primary neuron/glia cell culture experiments is highly desirable.
• Detail-oriented and rigorous approach to science, with the ability to work both      independently on bench tasks and collaboratively within a broader research team.
• Proficiency in reading and analyzing English scientific literature to guide experimental design.
• Strict adherence to biosafety standards and laboratory protocols.
• Highly adaptable, capable of managing time effectively to meet deadlines in a fast-paced research setting.
• Working knowledge of scientific data analysis software (e.g., Excel, GraphPad Prism) and familiarity with bioinformatics tools is preferred.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Please contact Ray Wu for more information:   ray.wu(at)branexbio.com

Role Summary

The Director / Senior Director of Protein Sciences will lead the production and characterization of next-generation biologics, including multispecific antibodies and engineered fusion proteins. This leader will shape BraneX’s protein sciences strategy, integrating innovation in antibody engineering, molecular design, and analytical characterization to enable rapid, high-quality therapeutic advancement. The role reports to the Chief Scientific Officer and works closely with internal teams in Biology, Assay Development, and CMC, as well as with external CROs, CDMOs, and other industry partners.

Key Responsibilities:

• Lead the expression, purification, and characterization of antibody-based therapeutics (monospecifics, bispecifics, Fc fusions, and conjugates).
• Drive innovation in biologics production — including heterodimerization control, conjugation (enzymatic, click, or linker-based), and modular payload formats (peptide, oligo, or protein).
• Build and oversee robust workflows for high-throughput protein production, analytical and developability characterization, integrating automation and informatics where appropriate.
• Apply biophysical, biochemical, and structural analyses (e.g., HPLC, MS, BLI, DSC, DSF, ITC, SPR, ELISA, CE-SDS) to ensure optimal developability and stability of molecules.
• Partner with CMC, toxicology, and translational functions to progress molecules toward IND-enabling studies.
• Establish and manage productive relationships with CROs and CDMOs for antibody discovery, characterization, and manufacturing.
• Identify and integrate emerging technologies (e.g., AI-driven design, machine learning-guided developability prediction, or microfluidics-based screening) to strengthen BraneX’s platform.
• Mentor and grow a high-performing Protein Sciences team while fostering scientific rigor, collaboration, and innovation.
• Ensure strong documentation and data integrity (ELN/SOP discipline) in support of IP, regulatory filings, and data room readiness.

Minimum Qualifications:

• PhD in Biochemistry, Molecular Biology, Structural Biology, or related field.
• ≥10 years of postdoctoral experience, including ≥5 years in a biotech or pharma setting with demonstrated impact in biologics discovery or engineering.
• Deep expertise in antibody and bispecifics expression, purification, and characterization; proven track record of advancing biologics toward development candidates.
• Demonstrated experience with biophysical and biochemical methods supporting protein stability, binding, and developability.
• Experience balancing internal and outsourced workflows and managing cross-functional scientific projects.
• Strong leadership, communication, and mentoring skills, with the ability to inspire a multidisciplinary team in a fast-paced startup environment.
• Strong ELN/SOP discipline and data-driven mindset.

Preferred Qualifications:

• Experience with early cell line development and technology transfer to manufacturing partners.
• Hands-on experience with protein conjugation and linker chemistry (e.g., for peptide or oligonucleotide cargoes).
• Familiarity with automation platforms (e.g., liquid handlers, chromatography automation, or analytics) for scale and reproducibility.
• Proven track record advancing biologics from discovery to IND or early clinical stage.

Success Metrics:

• Deliver 3–5 engineered leads per year meeting predefined developability and binding criteria.
• Achieve early-stage developability screening that mitigates liabilities (aggregation, PTMs, stability) pre-in vivo.
• Generate high-quality, traceable data packages and documentation supporting IP filings and partnership readiness.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Role Summary

The Director / Senior Director of Neuroscience Biology is responsible for the execution of the company’s overall research strategy focusing on neuroscience diseases. She/he will provide scientific leadership and build biology team for preclinical projects and supporting the initiation and advancement of innovative drug programs. This leader will participate to shape BraneX Bio’s therapeutics evaluation strategy, design and refine flow scheme assays to enable rapid, high-quality therapeutic advancement. The role reports to the Chief Operating Officer and works closely with internal biologics team as well as with external CROs, CDMOs, and other industry partners.

Key Responsibilities:

• Evaluate emerging scientific directions and technological trends relevant to neuroscience drug discovery.
• Lead the biology research team in new target discovery and validation, and establish relevant in vitro biological assays.
• Oversee the development and implementation of in vivo pharmacology models and efficacy testing methods.
• Manage the progress and timelines of the company’s R&D projects to ensure milestones are achieved efficiently.
• Collaborate with multidisciplinary experts to advance projects; participate in CRO selection, coordination and supervision to ensure scientific data quality and project milestone achievement.
• Maintain collaborations with domestic and international academic institutions and participate in the communications with scientific advisory board.
• Contribute to the growth of internal biology teams and laboratory infrastructure to support long-term R&D growth.

Minimum Qualifications:

• PhD in Biochemistry, Molecular Biology, Cell Biology, Neuroscience or related fields.
• ≥10 years of postdoctoral experience, including ≥5 years in a biotech or pharma setting with demonstrated impact in advancing portfolio programs into      PCC/IND stages.
• Deep expertise in CNS biology, including one or more of the following: neurobiology,      glia biology, neuroimmunology or CNS pharmacology.
• Hands-on experience with relevant in vitro and in vivo model systems of CNS diseases; familiarity with translational biomarkers and clinical relevance of preclinical findings.
• Strong communication skills in both English and Chinese, with demonstrated ability in organization, coordination, and team leadership.
• Strong analytical and logical reasoning abilities, high self-motivation, and a strong sense of responsibility.

Preferred Qualifications:

• Proven track record advancing therapeutics from discovery to early clinical stage.
• Strong ability to think strategically while maintaining operational excellence in project execution.
• International R&D experience and/or prior leadership in cross-site or cross-disciplinary collaborations preferred.

Success Metrics:

• Together with biologics team, deliver 3–5 engineered leads per year meeting      predefined pharmacology and developability criteria.
• Implementation of high-quality flow schemes and/or analytical platforms (e.g. AI analysis, advanced CNS models, novel technology platform ).
• Generate high-quality, traceable data packages and documentation supporting IP filings and partnership readiness.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Please contact Ray Wu for more information:   ray.wu(at)branexbio.com