Senior / Principal scientist, Biologics engineering

Role Summary

This position will be responsible for Biologics engineering and characterization. This position will report to Director of Biologics engineering and work closely with scientists from Biology and Protein Science teams. The position requires the candidate to carry out CADD/AIDD based Biologics engineering, including antibody humanization, affinity tuning, liability removal, and pH dependence; Biologics characterization, including binding assays, Tm, Tagg, HIC, DLS, and SPR.

Minimum Qualifications:

• PhD in Structure biology, Biochemistry, or related field with 2+ years post doc or industry experience, or Master with 5+ years in therapeutic antibody engineering.
• Proven record of any of the following: engineering antibodies/Fc-fusions, affinity / epitope tuning via structure guided engineering, phage / yeast / mammalian display technologies.
• Deep knowledge of antibody structure-function relationships and rational design, including utilization of protein design tools like PyMol, Alphafold, Discovery studio/Schrodinger/MOE, and etc.
• Solid wet lab training in any of the following: a. HPLC/UHPLC handling, including SEC, HIC, CIC, RP, CEX, and etc; b. SPR affinity determination; c. display library construction & screening, including phage, yeast or cell-based.
• Rigorous scientific thinking, highly self-motivated, and a strong sense of responsibility.

Preferred Qualifications:

• Programming skills to accelerate Biologics engineering.
• Strong communication skills in English.
• Flexibility and passion in continuous evolvement of technical platform.
• Awareness of whole process of therapeutical biologics Research & Development.

Success Metrics:

• Deliver 3–5 engineered leads per year that meet predefined binding kinetic + developability criteria. 
• Reduce aggregation/ liabilities pre-in vivo; demonstrate cross-reactive binders (e.g., human & cyno) for key targets. 
• High-quality documentation: traceable ELN, assay reports suitable for data room and IP filings. 

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Please contact Ray Wu for more information:   ray.wu(at)branexbio.com

Role Summary

The Director / Senior Director of Neuroscience Biology is responsible for the execution of the company’s overall research strategy focusing on neuroscience diseases. She/he will provide scientific leadership and build biology team for preclinical projects and supporting the initiation and advancement of innovative drug programs. This leader will participate to shape BraneX Bio’s therapeutics evaluation strategy, design and refine flow scheme assays to enable rapid, high-quality therapeutic advancement. The role reports to the Chief Operating Officer and works closely with internal biologics team as well as with external CROs, CDMOs, and other industry partners.

Key Responsibilities:

• Evaluate emerging scientific directions and technological trends relevant to neuroscience drug discovery.
• Lead the biology research team in new target discovery and validation, and establish relevant in vitro biological assays.
• Oversee the development and implementation of in vivo pharmacology models and efficacy testing methods.
• Manage the progress and timelines of the company’s R&D projects to ensure milestones are achieved efficiently.
• Collaborate with multidisciplinary experts to advance projects; participate in CRO selection, coordination and supervision to ensure scientific data quality and project milestone achievement.
• Maintain collaborations with domestic and international academic institutions and participate in the communications with scientific advisory board.
• Contribute to the growth of internal biology teams and laboratory infrastructure to support long-term R&D growth.

Minimum Qualifications:

• PhD in Biochemistry, Molecular Biology, Cell Biology, Neuroscience or related fields.
• ≥10 years of postdoctoral experience, including ≥5 years in a biotech or pharma setting with demonstrated impact in advancing portfolio programs into      PCC/IND stages.
• Deep expertise in CNS biology, including one or more of the following: neurobiology,      glia biology, neuroimmunology or CNS pharmacology.
• Hands-on experience with relevant in vitro and in vivo model systems of CNS diseases; familiarity with translational biomarkers and clinical relevance of preclinical findings.
• Strong communication skills in both English and Chinese, with demonstrated ability in organization, coordination, and team leadership.
• Strong analytical and logical reasoning abilities, high self-motivation, and a strong sense of responsibility.

Preferred Qualifications:

• Proven track record advancing therapeutics from discovery to early clinical stage.
• Strong ability to think strategically while maintaining operational excellence in project execution.
• International R&D experience and/or prior leadership in cross-site or cross-disciplinary collaborations preferred.

Success Metrics:

• Together with biologics team, deliver 3–5 engineered leads per year meeting      predefined pharmacology and developability criteria.
• Implementation of high-quality flow schemes and/or analytical platforms (e.g. AI analysis, advanced CNS models, novel technology platform ).
• Generate high-quality, traceable data packages and documentation supporting IP filings and partnership readiness.

What We Offer:

• Opportunity to lead cutting-edge biologics programs with true translational potential for CNS diseases.
• A collaborative, science-driven culture focused on impact, rigor, and innovation.
• Competitive compensation, equity participation, and comprehensive benefits.

Please contact Ray Wu for more information:   ray.wu(at)branexbio.com